The Psychiatric Risk Gene Transcription Factor 4 (TCF4) Regulates Neurodevelopmental Pathways Associated With Schizophrenia, Autism, and Intellectual Disability.

Schizophr Bull · 2018 · PMC6101561 · PMID 29228394

Europe PMC DOI

hedged sentences

0.0490

closest p · 1.0× alpha

0.0490

boldest claim

The sentences

nominally significantP = .049actually significant

39 MAGMA reported a nominally significant enrichment of TCF4 target genes amongst schizophrenia risk loci ( P = .049) after correcting for gene length and LD.

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highly significantno p-value reported

Enrichment analysis on the set of TCF4 targets identified numerous, highly significant functional clusters for pathways including nervous system development, ion transport and signal transduction, and co-expression modules for genes associated with synaptic function and brain development.

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