ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis.

While there was no significant difference in the severity of fusions between male and female mice, we observed a clear trend in reduced severity of fusions and reduced prevalence of fusions in female mice, a result that parallels known gender differences for the human disease 1 [Fig. 1g ].

also in 19,460 other papers