Arcuate nucleus and lateral hypothalamic CART neurons in the mouse brain exert opposing effects on energy expenditure.

Spontaneous food intake in absolute amounts measured over 24 hr showed a trend of increase in CNO-treated Arc→hM3Dq Cartpt cre/cre mice where CART is absent when compared to the same mice injected with saline ( Figure 4A ); this increase reached statistical significance when expressed as a percentage of BW ( Figure 4B ).

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