Notably, a significant increase in trabecular separation within the vertebrae was observed between sham Osx:Cre and sham EfnB1 OB −/− mice, while OVX EfnB1 OB −/− mice did not reach statistical significance.
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The osteoprogenitor-specific loss of ephrinB1 results in an osteoporotic phenotype affecting the balance between bone formation and resorption.
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