Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer's Disease: Post Hoc Analyses From a Randomized, Controlled, Clinical Trial of Patients Treated With Cholinesterase Inhibitors.

11 Memantine ER treatment resulted in statistically significant improvement in patient performance on the Severe Impairment Battery (SIB), the Clinician’s Interview-based Impression of Change Plus Caregiver Input (CIBIC-Plus), the Neuropsychiatric Inventory (NPI), and verbal fluency tests, compared with placebo; a trend toward improvement that did not reach statistical significance was seen on the Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL 19 ).

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