ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts.

PLoS One · 2018 · PMC6112648 · PMID 30153289

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did not reach statistical significanceno p-value reported

Although there was a trend to longer survival in mice bearing xenografts from newly diagnosed methylated tumors (Group I), the observed differences did not reach statistical significance, again suggesting that PARP inhibition may have a less profound effect on TMZ-sensitive tumors.

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