Spheroid Size Does not Impact Metabolism of the β-blocker Propranolol in 3D Intestinal Fish Model.

A value of p < 0.05 was considered significant, with data presented as p < 0.001 demonstrating highly significant results.

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Coefficient of variation between spheroids was recorded to denote comparability between experiments (and different passages) with an obvious trend toward minimization of variability in the larger size class ( Table 1 ).

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In this context, a clear trend emerges where larger spheroids demonstrated markedly distinct diffusional gradients which do not provide sufficient nutrients into the core of the aggregate.

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