Changes in plasma lipidome following initiation of antiretroviral therapy.

There was a trend towards a greater increase in LDL cholesterol in the efavirenz arm (0.30 mmol/L [IQR -0.20,0.56]) compared with the other treatment regimens which had stable or slight decreases in LDL cholesterol (atazanavir/r 0.16 mmol/L [IQR -0.40,0.89]; zidovudine/abacavir -0.07 [IQR -0.4,0.5]) but this did not reach statistical significance (p value = 0.510).

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Analysis of plasma lipidomes have identified previously undetectable, highly significant differences in lipid species and classes between HIV positive and negative participants as well as between individuals with and without coronary artery disease (CAD) [ 8 ].

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