PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.

Cell Death Dis · 2018 · PMC6115456 · PMID 30158592

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failed to reach statistical significanceno p-value reported

In parallel experiments, butein treatment exhibited a trend to reduce body weight gains compared with control treatments in low-fat diet (LFD) fed mice, but failed to reach statistical significance (Supplementary Figure S6 ).

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