Pervasive Modulation of Obesity Risk by the Environment and Genomic Background.

The authors of the omnigenic model noted that a few percent change in allele frequency at even a minority of the over 100,000 variants now expected to be associated with any complex trait could translate into highly significant divergence among populations [ 30 ].

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We extend their result with the observation of a similar pattern for less strongly associated SNPs that are nominally significant but do not pass genome-wide significance thresholds and hence are not formally associated with BMI.

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