However, the results of a clinical trial with Tarextumab, an antibody inhibiting NOTCH 2/3, although initially showed a trend towards an improvement of progression-free survival in patients whose tumors expressed elevated levels of NOTCH target genes, failed to confirm this trend in in a larger cohort of patients in the context of a phase II study [ 117 ].
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Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.
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