Barely Significant
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Ovalbumin-containing core-shell implants suitable to obtain a delayed IgG1 antibody response in support of a biphasic pulsatile release profile in mice.

PLoS One · 2018 · PMC6117011 · PMID 30161264

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a clear trendno p-value reported
However, as in the case of the in vitro data, a clear trend can be observed in the lag time between the core-shell formulations containing PLGA 50:50 and PLGA 100:0 as barrier.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.