Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific.

In sharp contrast, the lipid droplet content of infected macrophages decreased by 50% when the cells were treated with inhibitors of mTORC1 and caspase 8 (an initiator caspase) [the 30% decrease observed with treatment with a caspase 3 (an effector caspase) inhibitor did not reach statistical significance ( p = 0.09)] ( Fig 5A ).

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