Health-related quality of life in patients with iron deficiency anemia: impact of treatment with intravenous iron.

There was a significant improvement in LASA energy level ( P =0.01) and ability to perform ADL ( P <0.001), but the overall QOL ( P =0.07) did not reach statistical significance. 37 Such findings correlating hemoglobin level and fatigue as measured by the FACT-Fatigue scale were similarly demonstrated in an analysis based on a series of five placebo-controlled RCTs in various tumor types and whether or not patients were undergoing chemotherapy. 33 Larger community-based, open-label evaluations of ESA treatment similarly have demonstrated the correlation between increasing hemoglobin levels following ESA therapy and improvement in HRQOL.

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