NEDD9 promotes oncogenic signaling, a stem/mesenchymal gene signature, and aggressive ovarian cancer growth in mice.

Tumor growth slopes calculated for each individual mouse over the duration of the study revealed an overall delay in tumor growth rate in MISIIR-TAg;Nedd9 −/− mice that closely approached significance ( p =0.054, Fig. 1C ).

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Moreover, there was a dramatic difference in tumor dissemination in Nedd9 −/− mice, as evidenced by highly significant decreases in the average number of tumor nodules, ascites incidence and ascites volume in mice harboring Nedd9 −/− compared to Nedd9 +/+ controls ( Fig. 5G-I ).

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