Although the expression change of each gene considered individually was rather modest and did not reach statistical significance in most instances, we found a highly significant enrichment among the downregulated and upregulated genes in Snail OE and KD tumors, respectively, by encompassing all genes of the Dlk1-Dio3 locus in a gene set (Figure 1D ).
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Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells.
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