Genome-wide association study of developmental dysplasia of the hip identifies an association with <i>GDF5</i>.

Five SNPs showed evidence for nominally significant ( P < 0.05) association with the same direction of effect as the discovery cohort, compared with 1.35 under the null expectation (binomial test P = 0.01; Supplementary Table 4 ). rs143384 reached genome-wide significance in the replication dataset alone (effect allele A, EAF 0.61, OR [95% CI] 1.37 [1.24–1.51], P = 1.33 × 10 −10 ).

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