A gene co-expression module implicating the mitochondrial electron transport chain is associated with long-term response to lithium treatment in bipolar affective disorder.

This network achieved an IPA® network score of 35, indicating that the overlap between this network and the royalblue module genes is highly significant (i.e., an IPA® network score of > 2 corresponds to p < 0.01).

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We identified a nominally significant correlation between a co-expression module comprising 46 genes and lithium response represented as a continuous (i.e., scale ranging 0–10) phenotype (cor = −0.299, p = 0.035).

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