DNA methylation age is accelerated in alcohol dependence.

This difference was highly significant ( p <0.0001).

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The Grady Trauma project showed a trend in the same direction; however, age acceleration did not significantly differ between those with a diagnosis of ALC in their lifetime compared to those without (see Table 2 and Fig. 1 for additional information) Similar to the blood samples, The University of Minnesota LTCDS sample showed positive age acceleration in cirrhotic liver tissue and negative age acceleration in healthy liver tissue.

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