Conditional accumulation of toxic tRNAs to cause amino acid misincorporation.

Nucleic Acids Res · 2018 · PMC6125640 · PMID 30007351

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a clear trendno p-value reported

There was a clear trend of substitutions with lower scores (less frequently substituted to serine during evolution) causing greater toxicity, although different substitutions with the same BLOSUM score produced a range of toxicities ( Supplementary Figure S3B ).

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