Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization.

Alteration in psoriatic skin microbiome diversity is site specific and exhibits an increasing trend in alpha diversity and greater heterogeneity compared with healthy skin The diversity of the microbial community in a given human body site reflects the structure and composition of the community.

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Interestingly, we found significantly increased community richness (chao1) in scalp psoriatic lesions compared to healthy scalp and increased community evenness (Simpson and Shannon indices) in arm psoriatic lesional and non-lesional skin compared to arm healthy control skin, with a significant trend test in the arm for the Simpson and Shannon indices (Table 4 ).

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