PhenotypeSimulator: A comprehensive framework for simulating multi-trait, multi-locus genotype to phenotype relationships.

The P -values of all SNPs with simulated effect on the phenotypes in relation to their allele frequencies and simulated effect sizes can be found in the Supplementary Material (Simulation-and-LinearModel.pdf), showing a strong trend for SNPs with high allele frequencies and large simulated effect sizes to have low P -values. 4 Conclusion PhenotypeSimulator offers a framework for complex multi-trait, multi-locus phenotype simulations in quantitative genetics packaged in an easy to use manner for statistical geneticists.

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