Cx26 partial loss causes accelerated presbycusis by redox imbalance and dysregulation of Nfr2 pathway.

Briefly, it shows a highly significant p-value (9.5 × 10 −9 ) indicating a decrease in gene tissue expression for homozygous subjects carrying the alternative allele compared to those with the reference allele.

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Tg(Sox10-cre)1Wdr mice [14] and C57BL/6N mice (the genetic background shared by all animals in this study) showed a trend of age-related hearing loss in accord with a previous study which included C57BL/6N mice [68] and comparable to that of Gjb2 loxP/loxP animals ( Supplementary material, Fig.

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