Effects of isoflavones on breast tissue and the thyroid hormone system in humans: a comprehensive safety evaluation.

Arch Toxicol · 2018 · PMC6132702 · PMID 30132047

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

The authors reported an increase in breast density if compared to the controls in the long-term trials (3 years, two trials), but this effect did not reach statistical significance (MD 3.22%, 95% CI − 0.18 to 6.63, n = 241, p = 0.06).

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