GTEx annotation of nominally significant SNVs by genome-wide association study identified enriched expression of genes in multiple tissues including the heart and lung ( P = 2 × 10 −6 and P = 6 × 10 −4 , respectively (Suppl.
Age did not have a significant association with survival in previous PAH cohorts, such as the NIH or French Registries, but in a recent study from the French Registry age at diagnosis was highly significant. 24 – 26 The REVEAL registry associated poor survival with men aged > 60 years; previous experience at our institution has also suggested that age is an important factor in patients treated with epoprostenol. 27 , 28 This may be reflective of older patients having more advanced disease at the time of treatment initiation, but may also be due to the fact that PAH treatment is more efficacious now than 20 years ago and older patients may have worse survival due to co-morbidities rather than PAH alone.