IL-27 amplifies cytokine responses to Gram-negative bacterial products and Salmonella typhimurium infection.

typhimurium flagellin alone resulted in enhanced NF-κB/AP-1 activity and the addition of IL-27 resulted in a moderate upregulation of flagellin-induced NF-κB/AP-1 activity in both cell types, although this did not reach statistical significance in PMA-THP-1 cells (Fig. 2C,D ).

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