Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes.

First, we observed that the metabolomic profile of progressors and non-progressors differed significantly with respect to several metabolites; a logistic regression analysis resulted in 111 nominally significant metabolites after adjustment for age of diabetes onset, baseline HbA 1c and AER.

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The VSURF-selected metabolites erythritol, 3-phenylpropionate and N-trimethyl-5-aminovalerate were also consistently ranked among the highest in the RF and they were also highly significant in the logistic regression.

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