Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.

Furthermore, the secretion of collagen, as analyzed by Western blotting, showed a trend towards downregulation upon Nintedanib treatment but was not changed by Pirfenidone treatment in fibrotic 3D-LTCs (0.61 ± 0.16 and 1.28 ± 0.82 for Nintedanib and Pirfenidone, respectively; fold change upon treatment) (Fig. 1g ).

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