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Usefulness of Nonvalved Spacers for Administration of Inhaled Steroids in Young Children with Recurrent Wheezing and Risk Factors for Asthma.

Can Respir J · 2018 · PMC6140101 · PMID 30250631

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In addition, in these patients, more systemic steroids were needed and more severe events of bronchial obstruction that required hospital admission were seen, although they did not reach statistical significance, probably because of the sample size.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.