The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.

eNeuro · 2018 · PMC6140115 · PMID 30225353

Europe PMC DOI

hedged sentences

0.1700

closest p · 3.4× alpha

0.1700

boldest claim

The sentences

showed a trendp = 0.17not close (p > 0.1)

The number of total spines showed a trend toward being reduced in LGI1 -/- mice compared to WT neurons ( p = 0.17; Fig. 7 B ) .

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highly significantno p-value reported

However, coexpression of NgR1 and TROY causes a highly significant cellular contraction, suggesting that they interact and activate RhoA in COS7 cells.

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