After 8 h of oxLDL treatment average levels of phospho-MLKL tended to be higher in both wt or pdzk1 KO macrophages, however the differences did not reach statistical significance.
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Data on leukocyte PDZK1 deficiency affecting macrophage apoptosis but not monocyte recruitment, cell proliferation, macrophage abundance or ER stress in atherosclerotic <i>plaques of LDLR deficient mice</i>.
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We also saw an apparent trend towards increased levels of phospho-MLKL in pdzk1 KO compared to wt macrophages in the 24 h treatment samples that was not apparent in the 8 hr treatment samples, however the results did not reach statistical significance ( Fig. 9 ).