The Effect of Clown Intervention on Self-Report and Biomarker Measures of Stress and Fatigue in Pediatric Osteosarcoma Inpatients: A Pilot Study.

Integr Cancer Ther · 2018 · PMC6142113 · PMID 29900751

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Meantime, patients with metastatic osteosarcoma showed a trend for a decrease in MMP-9 levels between 1 and 9 hours after the clown intervention and restoration to basal levels after 13 hours ( Figure 3I ).

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