Limb-sparing surgery plus radiotherapy results in superior survival: an analysis of patients with high-grade, extremity soft-tissue sarcoma from the NCDB and SEER.

However, due to the small study size, these differences did not reach statistical significance. 26 While the initial results of the trial on preoperative RT vs postoperative RT showed increased survival in the preoperative RT group, 6 this survival benefit was not seen on longer follow. 28 However, this study was designed with a primary endpoint of major wound complications and was not powered to assess OS differences.

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