Efficacy of Bioactive Cyclic Peptides in Rheumatoid Arthritis: Translation from In Vitro to In Vivo Models.

There was no effect of either compound on peritoneal leukocyte numbers; although the linear compound decreased LPS-induced polymorpho-nuclear-leucocyte extravasation score in the liver and lung by 30–50%, this failed to reach statistical significance (data not shown).

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These results demonstrate clearly that, although micelles are good at presenting epitopes to cells in culture, there may be significant issues related to their use in vivo.

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