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Partial agonist activity of α1-adrenergic receptor antagonists for chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3.

PLoS One · 2018 · PMC6152952 · PMID 30248140

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Although the increase in luminescence signals for doxazosin did not reach statistical significance when the entire drug panel was compared with vehicle, doxazosin increased luminescence signals in PRESTO-Tango assays for CXCR4 1.5- fold , which was not significantly different from the luminescence signals induced by CXCL12 stimulation.

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