Population Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.

Antimicrob Agents Chemother · 2018 · PMC6153844 · PMID 30038039

Europe PMC DOI

hedged sentence

0.2100

closest p · 4.2× alpha

0.2100

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The sentences

did not reach statistical significanceP = 0.21not close (p > 0.1)

A similar maturation effect did not reach statistical significance for amodiaquine (ΔOFV = −3.1; 2 df; P = 0.21) and decreased the BSV on clearance only slightly, from 62.6% to 61.7%, but it was retained in the final model for consistency between the parent compound and the metabolite.

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