Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer.

J Cell Mol Med · 2018 · PMC6156353 · PMID 30055028

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0600

boldest claim

The sentences

borderline significanceP = .056so close (0.05 < p ≤ 0.1)

When we combined these two loci to estimate their joint effects on OS, patients carried two unfavourable genotypes (ie the PSEN1 rs165934 AA and MAML2 rs76032516 AC/CC) had a higher death risk (HR = 2.34, 95% CI = 1.53‐3.59, P < .001) than those without unfavourable genotype; patients carried one unfavourable genotype also had a higher death risk with a borderline significance (HR = 1.32, 95% CI = 0.99‐1.77, P = .056) than those without unfavourable genotype; and the trend test was statistically significant ( P < .001).

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a borderline significant trendP = .060so close (0.05 < p ≤ 0.1)

We further explored the genetic expression correlated with the change of rs165932 A to C (in high LD with rs165934, r 2 = .946) in the ovarian tissues (23 CC, 57AC and 42 AA carriers), and we found that PSEN1 expression levels increased with a borderline significant trend ( P = .060) (Figure 4 B).

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