In the PFC, the outcome was similar, aside from enhanced expression of Ntf3 observed in all male mice (two-way ANOVA: genotype F (3,38) = 5,98, p < 0.01) but not female mice (however, the results did not reach statistical significance in w/t and Creb1 TPH2CreERT2 mice exposed to fluoxetine treatment) ( Figures 3A–E ).
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Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment.
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