Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.

Mol Neurodegener · 2018 · PMC6158915 · PMID 30257685

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We independently confirmed this result by using deltarasin, a compound structurally unrelated to REM, which also binds in Pde6δ’s prenyl-binding pocket [ 40 ] and, similarly to REM, showed a trend towards counteracting cell-death in our model of neurotoxicity (Fig. 3c ).

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