Apolipoprotein E Epsilon 4 Genotype, Mild Traumatic Brain Injury, and the Development of Chronic Traumatic Encephalopathy.

To date, of the 5 military studies with MTBI evaluated in the current review, the influence of APOE-ε4 status on outcome after MTBI remains unclear: one study of 458 active-duty subjects showed a trend of increased prior concussions in ε4-carriers, one study of 87 veterans showed interaction between ε4, PTSD and DNA methylation, one study of 120 veterans showed interactions between ε4 status and diagnosis of TBI and PTSD, one study of 53 active-duty subjects showed a relationship between job status and memory performance associated with ε4-carriers, and one study on cortical thickness was negative.

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