Circulating iron levels influence the regulation of hepcidin following stimulated erythropoiesis.

Consistent with this, we detected an increase in the expression of Tfr1 (normalized to Hprt ) ( Figure 8A ) in the spleen of mice treated with both erythropoietin and iron when compared to those treated with erythropoietin alone, although the increase failed to reach statistical significance ( P =0.089).

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