A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects.

Inflamm Bowel Dis · 2017 · PMC6166688 · PMID 29272475

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.1500

boldest claim

The sentences

a trend towards significanceP = 0.07so close (0.05 < p ≤ 0.1)

2B ), even though there was a trend towards significance in CD patients (vehicle: 82.5, C48/80: 121.7, C48/80+β-glucan: 110.8), P = 0.07.

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a nonsignificant trendP = 0.15not close (p > 0.1)

Preincubation with β-glucan prior incubation with C48/80 resulted in a nonsignificant trend, P = 0.15, of lower release of β-hexosaminidase compared to cells stimulated with C48/80 only ( Fig. 7A ).

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showed a trendno p-value reported

HMC-1.1 experiments showed a trend to decreasing MC-degranulation and levels of TNF-α but not IL-6 by β-glucan.

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a weak trendno p-value reported

However, after 1 hour, only a weak trend remained towards decreased transport of β-glucan in both models ( Fig. 6E ).

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