Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using <sup>18</sup>F-ICMT-11 and <sup>18</sup>F-FLT PET.

However, when studied ex vivo by γ-counting, both monotherapy and combination therapy showed highly significant effects on tracer retention (Supplemental Fig. 3; P < 0.0001 and P = 0.0007, respectively), but there was no difference between treated tumors with and without gemcitabine ( P = 0.9).

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Although cetuximab alone or in combination with gemcitabine had no effect on plasma thymidine concentrations, a small decrease in plasma thymidine concentrations (approaching significance, with P = 0.055) was observed after 24 h of gemcitabine treatment ( n = 3–8), a finding that is similar to those of Schelhaas et al.

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