Activation of podocyte Notch mediates early Wt1 glomerulopathy.

Increased levels of other Notch basic helix loop helix (bHLH) transcription factors Hes1 , Hes3 , Hes5, and HeyL were also observed in primary mutant podocytes but not in controls ( Figure 3 a), although these changes did not reach statistical significance.

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