only marginally significantP < 0.06
While the difference between these two enrichments is only marginally significant (one-tailed Z -score P < 0.06), H3K27ac marks alone capture more variants than H3K27ac overlapping DHS variants (7.7% vs. 5.8%) but explains a smaller heritability fraction (44.3% vs. 48.8%) ( Fig. 6 C; Supplemental Fig.