2 Another study focusing on HNSCC showed that only the HNSCC patients with the FGFR4 Arg388 allele died in the follow‐up period, and showed a trend to a reduced overall survival. 7 Accordingly, in a study specifically focusing on the association between the FGFR4 Arg388 allele with oral squamous cell carcinoma (OSCC) development, it was shown that, compared with OSCC patients carrying the Gly/Gly genotype, the patients carrying the FGFR4 Arg/Arg or Arg/Gly genotype had advanced nodal stage (pathologic N2 + N3).
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