Repurposing of promoters and enhancers during mammalian evolution.

In primates, we find a significant trend in U1 motif distribution around orthologous P/E elements similar to that detected in rodents (Fig. 4e ) but no difference in PAS density (Supplementary Fig. 9 ), probably due to the low sequence divergence between human and macaque and the resulting lack of power 36 .

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