Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.

Here, despite the sample size limitation, we observed consistent GO or disease enrichments using different web-based tools or different gene lists, indicating that the nominally significant findings ( P < 1 × 10 −4 ) and the coexpressed genes with GRIA4 are robustly related to the ND+MD trait.

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