Large-scale transcriptome-wide association study identifies new prostate cancer risk regions.

We found a highly significant replication (mean R 2 = 0.07; P = 1.5 × 10 −29 ), explaining 41% of in-sample cross-validation R 2 (Supplementary Figure 3 ), which is consistent with previous out-of-sample estimates 24 , 25 .

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Genes with nominally significant ( P < 0.05) estimates of SNP-heritability (cis- \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$h_g^2$$\end{document} h g 2 ), are then put forward for training predictive models.

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