Fenofibrate improves vascular endothelial function and contractility in diabetic mice.

Also, fenofibrate treatment decreased serum creatinine compared with vehicle-treated DM (26 ± 2 versus 22 ± 0.9 μmol/L, p < 0.01) and showed a trend towards lower serum urea nitrogen ( Table 1 ). 3.2 Fenofibrate treatment improves vascular dysfunction of aortas in diabetic mice Eight-week fenofibrate administration markedly improved endothelium-dependent relaxation (EDR) by acetylcholine in DM aortas without affecting responses in control mice ( Fig. 1 A, p < 0.001).

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